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Outcome measure

Gravimetric Sweat Production (GSP)

Gravimetric Sweat Production (GSP) is the objective sweat-rate measure used across hyperhidrosis trials. The method weighs absorbent material before and after a defined collection interval to quantify sweat output in milligrams over time.

Type
objective measure
Consumer-facing?
No
Primary use
objective sweat-rate measurement (mg over a defined interval)

Methodology

GSP collects sweat onto pre-weighed filter paper (or similar absorbent material) over a standardized interval — typically 5 minutes — under controlled conditions. The post-collection weight minus the pre-collection weight gives the sweat mass; converting to a rate (mg/5min) allows comparison across treatments, patients, and time points.

Why GSP complements patient-reported measures

GSP is objective: it measures actual sweat output rather than perceived severity. HDSS, HDSM-Ax-7, and ASDD capture lived experience; GSP grounds that experience in a measurable biological output. Trials often pair the two to demonstrate both objective reduction and patient-perceived benefit.

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